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CFM is continuously investigating new drug compounds to ensure cutting edge therapies in trauma care at great length.
Traumatic injuries have major health consequences. Although primarily a disease of younger adults, its morbidity and mortality are increasingly severe at the extremes of age. Expert multidisciplinary trauma care is recognized as the most important determinant of survival.
The epidemiology and modern management of traumatic Hemorrhage
Hemorrhage is a major factor of traumatic injury and its care.
Hemorrhagic shock, in addition to directly resulting in early fatality, is a predictor of poor patient outcome. Early hypotension (systolic blood pressure = 90 mmHg) with hemorrhage in the field or at initial hospital evaluation is associated with complications such as eventual organ failure and the development of infections, including sepsis.
Next to the consequences of shock itself, current management of hemorrhagic shock in traumatic injury relies heavily on transfusion of red blood cells (RBCs). These transfusions are associated with the development of multiple organ failure (MOF), increased intensive care unit (ICU) admissions and increased hospital length of stay, and finally mortality.
As the patient progresses through the phases of trauma care, death from causes unrelated to specific injuries becomes more common. Infections like sepsis and pneumonia, systemic inflammatory response syndrome, and MOF are becoming the primary etiologies of traumatic death in hospitalized trauma patients.
The hemorrhaging trauma patient frequently has injuries that require urgent surgery for control of bleeding, and more than 80% of trauma deaths that occur in the operating room do so as a result of hemorrhage. These severe injuries comprise a category known as ‘surgical bleeding’ and account for about 50% of hypotensive patients.
If surgical bleeding is not controlled in this manner, it will likely be fatal. Given the large proportion of operative deaths secondary to hemorrhage, prevention of these fatalities is a clear area that needs improvement. Early intervention to control bleeding is crucial.
Patients with hemorrhage have a major risk for renal insufficiency.
A major medical procedure used to help Trauma and MI patients is Angioplasty, which can cause renal failure as well. Next to that, there is a strong association between both acute and chronic dysfunction of the heart and kidneys with respect to morbidity and mortality.
This contrast-induced nephropathy is responsible for 11% of hospital-acquired renal insufficiency, and is the third leading cause of hospital-acquired renal failure.
Therefore The Erasmus Medical Centre in Rotterdam has investigated the effects of BMOV in to preventing kidney failure. Encouraging results from CFM’s latest preclinical study, showed significant protection against renal injury.
CFM is planning Phase II and III studies on Ischemic Kidney tissue repair together with the Erasmus Medical Centre
‘Intensive care department’ in Rotterdam, the Netherlands.